Radiochemistry Laboratories

CIC biomaGUNE has a radiochemistry laboratory equipped with 5 shielded hot cells housing versatile automatic synthesis, suitable for the production (synthesis, purification and quality control) of PET and SPECT radiotracers. The facility has specially designed modules for:

Synthesis of [¹¹C] CH₃I / [¹¹C] CH₃OTf from [¹¹C] CO₂ / [¹¹C] CH₄, and subsequent methylation reaction
¹⁸F-fluorination by nucleophilic and electrophilic substitution
Radiotracer synthesis using microfluidics technology
Chelation reactions using radiometals (⁶⁸Ga, ⁶⁷Ga, ⁶⁴Cu, ⁸⁹Zr, etc)

In addition, the laboratory has two shielded hot cells for manual handling of radioactive substances, suitable for the preparation of mono-doses or to perform syntheses with small amounts of radioactivity.

The quality control lab sited into the production lab is equipped with state-of-the-art equipment to perform the complete quality control of the synthesized radiotracers, including the following equipment.

Additionally, CNIC hosts a radiochemistry/nanochemistry lab which includes a relaxometer of 1.5 Tesla, nanosizer ZS-90, homogenizer, ⁶⁸Ga generator and a synthesis module equipped with an organic chemistry lab.

Low resolution multichannel λ spectrometry

Measures very small amounts of sodium iodide, and to perform radioimmunoassays. Storage capacity of 55 racks; 10 simu...

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